What medical conditions cause blisters?

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asked Aug 7 in Body/Skin by Rogowski (580 points)
What medical conditions cause blisters?

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answered Aug 25 by Gingervitis (7,160 points)
Medical conditions that cause blisters are sunburns, scalds, burns, friction, Atopic Dermatitis, Impetigo, Pemphigus and Pemphigoid.

Pemphigoid will appear as and look like sore itchy patches on the skin and if your skin is white skin the sore itchy patches with Pemphigoid will look appear as red or pink in color and on black skin they will look like dark reddish brown.

Pemphigoid is a rare autoimmune disorder that can develop at any age, including in kids, but that most often affects the elderly.

Pemphigoid is caused by a malfunction of the immune system and results in skin rashes and blistering on the legs, arms, and abdomen.

Bullous pemphigoid is an autoimmune disorder that occurs when the body's immune system attacks and destroys healthy body tissue by mistake.

Specifically, the immune system attacks the proteins that attach the top layer of skin (epidermis) to the bottom layer of skin.

Bullous pemphigoid often goes away on its own in a few months, but may take as many as five years to resolve.

Treatment usually helps heal the blisters and ease any itching.

It may include corticosteroid medications, such as prednisone, and other drugs that suppress the immune system.

What is difference between pemphigus and pemphigoid?

Pemphigus is characterized by shallow ulcers or fragile blisters that break open quickly.

Pemphigoid presents with stronger or “tense” blisters that don't open easily.

Those with pemphigoid are also more likely to have hot, red and itchy hive spots.

Topical corticosteroids, systemic corticosteroids, and doxycycline are the mainstays of initial treatment for bullous pemphigoid.

Additional immunomodulatory therapies are often added to minimize the adverse effects of chronic corticosteroid therapy or to augment improvement in the disease.

Pemphigus and pemphigoid are diagnosed through special testing and clinical presentation.

Types of testing include: Lesion biopsy — a sample of the blistered skin is removed and examined under the microscope.

Additionally, the layer of skin in which cell-to-cell separation occurs can be determined.

If you have blisters in your mouth, avoid eating hard and crunchy foods, such as chips and raw fruits and vegetables, because these types of foods might aggravate symptoms.

Oral terbinafine has been associated with the development of bullous pemphigoid. Vancomycin is the most common cause of drug-induced LAD.

Other drugs known to cause LAD include diclofenac, somatostatin, lithium, phenytoin, captopril, amiodarone, cefamandole, amoxicillin, and ampicillin-sulbactam.

Thus, risk factors for BP include neurological disorders, particularly dementia and Parkinson's disease, psychiatric disorders (unipolar and bipolar disorders), bedridden condition, and chronic use of several drugs.

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