End stage amyloidosis is the final stage of amyloidosis, which is a disease in which abnormal protein deposits called amyloid build up in your organs and cause significant damage and dysfunction.
At the end stage of amyloidosis the damage is often irreversible and can lead to severe organ failure and even fatal complications.
Symptoms of end stage amyloidosis are severe heart failure, irregular heartbeat, fluid retention due to the heart's inability to pump blood effectively, significant kidney dysfunction, often leading to nephrotic syndrome, "kidney disorder that causes protein loss in urine" and severe edema also called swelling.
Amyloidosis can also affect your other organs such as your lungs, liver and your gastrointestinal tract and cause a range of symptoms including digestive issues, breathing difficulties and even liver damage.
Other symptoms of end stage amyloidosis are abdominal swelling and pain, extreme fatigue, unexplained weight loss and dizziness upon standing.
The prognosis for end stage amyloidosis is often poor and has a high morbidity and mortality rate.
The treatment for end stage amyloidosis also focuses on managing the symptoms and slowing the progression of amyloidosis and improving your quality of life.
In some cases an organ transplant like a kidney transplant or heart transplant may also be considered.
Amyloidosis can progress pretty quickly for some types of amyloidosis and other types of amyloidosis may progress more slowly.
Some types of amyloidosis such as AL amyloidosis can progress rapidly and other types of amyloidosis such as ATTR amyloidosis often progress more slowly.
AL amyloidosis can progress from stage 1 to stage 4 in just months and other forms of amyloidosis like ATTR amyloidosis can take years to show any significant symptoms and progress too far.
The vitamins that are good for amyloidosis are vitamin B12, vitamin K3, vitamin A, vitamin E, vitamin D and vitamin C.
Vitamin C can improve immune function and reduce inflammation associated with amyloidosis.
Vitamin D can help clear amyloid plaques from your brain.
Vitamin E, similar to vitamin A, has antioxidant effects and can reduce amyloid plaque formation.
Vitamin A possesses antioxidant properties which can help protect cells from damage that is caused by amyloid proteins.
Vitamin K3 can inhibit amyloid protein aggregation and vitamin B12 plays a role in protein metabolism and can help to reduce amyloid protein accumulation.
The vitamin deficiency that causes amyloidosis is vitamin A which has been linked to wild type amyloidosis.
Also vitamin D deficiency, vitamin C deficiency and even vitamin B12 deficiency can cause amyloidosis.
Vitamin D deficiency is common in people with renal AL amyloidosis.
And vitamin C deficiency can accelerate amyloid accumulation and deposition.
And vitamin B12 deficiency can influence amyloid beta toxicity in Alzheimer's disease, most particularly in the context of hyperhomocysteinemai.
Vitamin B12 deficiency and Amyloid beta beta Toxicity is linked an increased oxidative stress and can accelerate amyloid accumulation and deposition.
A deficiency of vitamin C can result in increased oxidative stress and can accelerate amyloid accumulation and deposition.
Vitamin C plays a role in protecting the body against oxidative stress.
Vitamin D deficiency and Hypovitaminosis D is also observed frequently in people AL amyloidosis, most particularly in people with kidney involvement.
And wild type amyloidosis involves the misfolding of the transthyretin TTR protein.
The TTR protein normally carries retinol which is a form of vitamin A, throughout the body.
And when TTR misfolds, it can't transport the retinol properly, and can lead to a vitamin A deficiency and even contribute to the progression of wild type amyloidosis.