Certain antiparasitic drugs such as diethylcarbamazine (DEC) are what paralyzes parasites.
These antiparasitic drugs like diethylcarbamazine (DEC) paralyzes parasites by causing calcium to enter the parasites muscle cells, which then lead to muscle retraction and temporary paralysis.
A drug called Ivermectin paralyzes worms by disrupting the worms nerve and muscle functions.
And a substance derived from rotifers called Schistosome Paralysis Factor can also paralyze the schistosome parasite, and other chemicals and substances are also being researched to understand and also exploit this mechanism further.
Diethylcarbamazine (DEC) is a drug that temporarily paralyzes parasitic worms by opening transient receptor potential (TRP) ion channels in the parasites muscle cells.
The influx of calcium into these parasites cells triggers muscle retraction, leading to paralysis that allows the host's body to expel the parasites.
Ivermectin is a medication that acts on the nervous and muscular systems of worms, causing paralysis and eventual death.
Pyrantel Pamoate is a common drug that used for intestinal parasites like pinworms that paralyzes the worms, allowing them to be passed out of the body in stool.
Schistosome Paralysis Factor is a substance that was discovered in a rotifer that can paralyze the schistosome parasite by acting on its serotonin receptors.
Researchers are also still studying its potential for treating schistosomiasis, a parasitic disease.
The mechanisms of paralysis of parasites includes.
Muscle cell involvement.
The paralysis often results from the drug or substance affecting the parasite's muscle cells.
Ion channel disruption.
Drugs like DEC work by opening specific ion channels, like TRP channels, which allows calcium to enter the muscle cells, leading to their retraction and paralysis.
Neurotransmitter interference.
And some types of compounds, like SPF, interfere with the parasite's nervous system, potentially by acting on receptors like serotonin receptors, which control movement.