The autoimmune disease that has high eosinophils is Eosinophilic Granulomatosis with Polyangiitis (EGPA) as well as Eosinophilic Fasciitis, Bullous Pemphigoid, Inflammatory Bowel Disease, Dermatomyositis and Rheumatoid Arthritis and Sjogren's Syndrome.
Rheumatoid Arthritis and Sjogren's Syndrome are systemic autoimmune diseases that primarily cause joint inflammation and severe dry eyes and dry mouth, and can be accompanied by elevated eosinophils in a minority of people.
Dermatomyositis is an inflammatory connective tissue disease, which causes distinct skin rashes and muscle weakness, which is occasionally accompanied by eosinophilia.
And both Crohn's disease and ulcerative colitis also feature chronic inflammation of your digestive tract and in some cases, this immune dysfunction leads to high eosinophil counts.
Bullous Pemphigoid is an autoimmune blistering skin disease where the immune system attacks the layer of skin between your epidermis and dermis and it causes severe itching and large, fluid filled blisters.
Eosinophilic Fasciitis, is a rare connective tissue disease, in which the fascia, which is the tough tissue that covers muscles becomes inflamed, which leads to thickened skin and restricted joint movement.
Eosinophilic Granulomatosis with Polyangiitis (EGPA) is also called Churg-Strauss syndrome and is the most common autoimmune cause of extreme eosinophil counts and is a rare form of vasculitis, which is inflammation of the blood vessels that severely affect your lungs, sinuses and nerves.
Eosinophilia is simply a medical term for having high levels of eosinophils, which are a type of white blood cell in your blood or tissues.
Mild elevations of eosinophils often indicate common and manageable issues like a parasitic infection or allergies, but severe and persistent levels of eosinophils can result in dangerous organ damage.
Eosinophilia is not a lung disease or disease itself, although eosinophilia is closely tied to certain and specific conditions that are called Eosinophilic Lung Diseases.
When the eosinophils accumulate in your lung tissue or airways, the accumulation of the eosinophils trigger inflammation, which can lead to a spectrum of respiratory issues, which are often referred to collectively as pulmonary eosinophilia.
The following conditions can result from eosinophilia, which include acute Eosinophilic Pneumonia, Chronic Eosinophilic Pneumonia, Simple Pulmonary Eosinophilia also known as Loffler's syndrome and Hypereosinophilic Syndrome.
Acute Eosinophilic Pneumonia is a severe and rapidly progressive illness, which causes respiratory failure, fever and severe difficulty breathing and it often occurs suddenly as a reaction to inhaled smoke, toxins, medications or even new environmental triggers.
Chronic Eosinophilic Pneumonia develops over weeks or even months and causes coughing, shortness of breath, night sweats and weight loss.
Simple Pulmonary Eosinophilia also known as Loffler's syndrome is a mild form that often comes and goes without any noticeable symptoms.
And hypereosinophilic syndrome is a rare disorder that is marked by persistently high eosinophil counts that can also damage multiple organs, which include your lungs.
And sometimes having elevated eosinophils in your lungs is a secondary effect of an underlying condition, exposure or even infection.
Eosinophilia is the elevated level of eosinophils which are a type of white blood cell in your blood or tissues and a high eosinophil count often means that your immune system is responding to an inflammatory trigger.
Allergic and inflammatory conditions, parasitic and fungal infections, medication and drug reactions, malignancies and hematologic disorders and even primary immunodeficiencies and even idiopathic hyperesoinophilic syndrome can lead to eosinophilia.
Although eosinophils are crucial in the body for fighting off certain parasites and also for controlling infections, excessively high levels of eosinophils also known as eosinophilia can result in them infiltrating and damaging of health tissue, which leads to severe localized or even systemic complications.
When the eosinophils migrate out of your bloodstream and into your tissues, they will release toxic proteins, which cause chronic inflammation and organ damage.
The specific health issues that eosinophilia causes, depends on where the cells actually accumulate.
Heart damage or cardiovascular damage is the most dangerous complication with eosinophilia.
High eosinophil levels can cause inflammation of your heart muscle, which is also known as myocarditis, heart failure and even blood clots, which also increase your risk of heart attacks or stroke.
lung and respiratory issues can also occur with eosinophilia as infiltration of the airways causes severe inflammation, mucus hypersecretion and even airway constriction, which significantly worsens conditions such as asthma.
Gastrointestinal complications can also occur with eosinophilia, as excess eosinophils in your digestive tract can trigger Eosinophilic Gastrointestinal Diseases, which causes severe acid reflux, swallowing difficulties, stomach pain and even tissue damage.
Infiltration can also cause skin problems, like chronic rashes, severe itching or pruritus, hives or angioedema "swelling.
And in severe cases of eosinophilia, like Hyper eosinophilic Syndrome, eosinophils can also affect your brain and your nerves, potentially resulting in confusion, nerve damage or behavioral changes.
And chronic or extreme levels of eosinophils may also be a warning sign for underlying bone marrow disorders like chronic Eosinophilic Leukemia and myeloproliferative diseases.